The SportsLine model has released its college football (CFB) picks for the USC Trojans vs. Colorado Buffaloes game.
Deion Sanders is coaching the Buffaloes, who are looking to recover from their first loss of the season.
Caleb Williams, the reigning Heisman Trophy winner, aims to make a case for winning the award again as he leads the USC Trojans.
Williams, a 6-foot-1 junior from Washington, D.C., is excelling in passing categories despite limited playing time.
USC has an undefeated record of 4-0, with hopes of making it to the College Football Playoffs.
The Colorado Buffaloes have tripled their win total from the previous season, standing at 3-1.
Kickoff for the game is scheduled at noon ET.
USC Trojans are the favorites with a 21.5-point spread according to SportsLine consensus.
The over/under for total points scored in the game is set at 73.
The SportsLine Projection Model, which simulates FBS college football games 10,000 times, has a successful track record